منابع مشابه
Neural Stem Cells (NSCs) and Proteomics*
Neural stem cells (NSCs) can self-renew and give rise to the major cell types of the CNS. Studies of NSCs include the investigation of primary, CNS-derived cells as well as animal and human embryonic stem cell (ESC)-derived and induced pluripotent stem cell (iPSC)-derived sources. NSCs provide a means with which to study normal neural development, neurodegeneration, and neurological disease and...
متن کاملQuiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain.
Adult primitive neural stem cells (pNSCs) are a rare population of glial fibrillary acidic protein (GFAP)- Oct4+ cells in the mouse forebrain subependymal zone bordering the lateral ventricles that give rise to clonal neurospheres in leukemia inhibitory factor in vitro. pNSC neurospheres can be passaged to self-renew or give rise to GFAP+ NSCs that form neurospheres in epidermal growth factor a...
متن کاملSystematic Analysis of mRNA and miRNA Expression of 3D-Cultured Neural Stem Cells (NSCs) in Spaceflight
Recently, with the development of the space program there are growing concerns about the influence of spaceflight on tissue engineering. The purpose of this study was thus to determine the variations of neural stem cells (NSCs) during spaceflight. RNA-Sequencing (RNA-Seq) based transcriptomic profiling of NSCs identified many differentially expressed mRNAs and miRNAs between space and earth gro...
متن کاملNeural Stem Cells: A Functional Definition Based on Proteomics
Neural stem cells can be isolated from the adult mammalian brain throughout the entire lifetime of an organism, including humans. Unfortunately, no unique molecular marker could be identified expressed by all types of neural stem and progenitor cells in every developmental stage. Genomic and proteomic screening approaches suggest a functional definition of adult stem cells by their molecular in...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2016
ISSN: 1535-9476
DOI: 10.1074/mcp.o115.052704